Acidul ursodeoxicolic posedă acţiune hepatoprotectorie in leziunile hepatice de diferită geneză, totodată avand efect favorabil in tratamentul bolnavilor cu boală hepatică alcoolică, ameliorand semnificativ injuria hepatică. Obiectivul studiului este de a evalua eficacitatea clinică şi biochimică a acidului ursodeoxicolic in tratamentul pacienţilor cu boală alcoolică a ficatului. La pacienţii cu hepatită cronică de geneză alcoolică s-a stabilit că tratamentul complex cu UDCA a exercitat un efect benefic in evoluţia sindroamelor clinice, marcherilor de citoliză şi colestază, ceea ce confirmă efectul hepatoprotector şi anticolestatic al acidului ursodeoxicolic.

Ursodeoxycholic Acid (UDCA) has been shown to have hepatoprotective effects in various liver diseases. This drug has also been found to be effective in patients with alcoholic hepatitis, improving hepatic disease significantly. The aim of this study was to evaluate clinical and biochemical efficiency of UDCA in treating patients with alcoholic liver disease. In patients with chronic hepatitis of alcoholic genesis it was found that complex treatment with UDCA has a benefic effect on the evolution of clinical syndromes, markers of cytolysis and cholestasis comparing with patients who haven’t receive this medicine, that demonstrates the hepatoprotective and anticholestatic action of ursodeoxicolic acid.