The purpose of this study was to prezent the genetic bazis of atherosclerosis with progressive evolution of CHD and acute ischemic myocardial stroke (IMS) at patients in younger age and evidence the roles of small,dense LDL and plazma trygliceride as major risc factors for CHD.These data demonstrate a higher polymorphisms of genes-candidate for atherosclerosis in association with atherogenic dyslipidemic phenotype and premature CHD and IMS.It was related an increase incidence of CHD in familial ereditary disease, determinated by LPL-familial insufficiency and in familial ApoE defficiency.