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616.72-002.77-085 (4) |
Patologia organelor de locomoţie. Sistemul osos şi locomotor (472) |
SM ISO690:2012 CRACEA (DRUŞCA), Angela, REVENCO, Ninel. Rolul tratamentului cu preparatul antioxidant vita grapes în modificarea indicilor antioxidanţi în artrita juvenilă idiopatică . In: Buletin de Perinatologie, 2019, nr. 3(84), pp. 42-47. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 3(84) / 2019 / ISSN 1810-5289 | ||||||
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CZU: 616.72-002.77-085 | ||||||
Pag. 42-47 | ||||||
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Background. Juvenile Idiopathic Arthritis is considered a chronic disease, disabling, with a high socio-economic impact. Antioxidant barrier is a complicated system of enzymes, elements and substances that are formed to protect aerobic organisms against increased oxygen concentrations, resulting in the production of free radicals of oxygen. Material and methods. 50 patients with Juvenile Idiopathic Arthritis were selected. The children were divided into 4 groups: group I ‒ 14 children with Juvenile Idiopathic Arthritis who received treatment with Metotrexat and Vita Grapes ‒ antioxidant drug; group II ‒ 12 children treated with Metotrexate, Prednisolone and Vita Grapes; group III ‒ 11 children only treated with Methotrexate; group IV ‒ 13 children treated with Metotrexate and Prednisolone. Results. Analytical confrontation of antioxidant indicators among groups studied at 3 months of treatment determined their increase in groups I and II, which administered the Vita Grapes antioxidant drug, compared to groups III and IV, which did not follow antioxidant treatment (p>0,05). Conclusion. Vita Grapes has positively influenced antioxidant indicators by increasing catalase and ceruloplasmin values and modulating total antioxidant activity, superoxide dismutase, glutathione peroxidase and glutathione reductase, thus exhibiting strong antioxidant activity. |
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Cuvinte-cheie Juvenile idiopathic arthritis, antioxidant indicators, treatment, идиопатический ювенильный артрит, антиоксидантивные показатели, лечение |
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