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Căutarea după subiecte similare conform CZU |
616.379-008.64:618.2 (2) |
Patologia sistemului digestiv. Tulburări ale tubului alimentar (1746) |
SM ISO690:2012 ROŞCA, Daniela, SERBENCO, Anatol. Statutul lipidic matern prenatal în sarcina complicată cu diabet zaharat. In: Buletin de Perinatologie, 2018, nr. 3(79), pp. 27-33. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 3(79) / 2018 / ISSN 1810-5289 | ||||||
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CZU: 616.379-008.64:618.2 | ||||||
Pag. 27-33 | ||||||
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Introduction: diabetes mellitus (DM) is considered an important factor contributing to the impairment of maternal lipid metabolism with a frequent negative impact on fetal development. Objective of the study: analysis of some particularities of lipid metabolism in pregnant with different types of DM. Materials and methods: prospective cohort study was conducted: 96 pregnant with diabetes (baseline group) and 96 pregnancies without diabetes (control group) who delivered in Institute of Mother and Child Care, Chişinău, Republic of Moldova. The baseline lot was divided into 3 subgroups, depending on type of DM : 31 (32.3%) of the pregnant with DM type I (sublot 1), 15 (15.6%)of the pregnant with DM type II (sublot 2) and 50 (52.1%) of patients with gestational diabetes mellitus (GDM) (sublot 3). Results: the analysis of prenatal lipid status in pregnant with DM revealed a total increase in TG values of -2.53 ± 0.69mmol / L (1.75-5.68mmol / L) compared to nondiabetic pregnancies, which had TG - 2.21 ± 0.28mmol / L (1.652.76mmol / L), p <0.0001 and LDL cholesterol, respectively 4.64 ± 0.84mmol / L (1.38-7.43mmol / L) versus 4.07 ± 0.67 1.72-5.02 mmol / L), p<0.0001. HDL cholesterol was lower in pregnant women in the baseline group, namely 1.54 ± 0.55mmol / L (0.41-3.44mmol / L), compared with the control group - 2.22 ± 0.74 mmol / L (0.31-3.44mmol / 37mmol / L), p<0.0001. There was a higher increase in TG in mothers with DM who gave birth to large-for-gestational age newborns, both in cases of delivery prematurely and in term. Conclusion: Pregnancy in women with DM is associated with more pronounced changes in lipid metabolism, predominantly the increase in TG and LDL cholesterol and the decrease in HDL cholesterol. |
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Cuvinte-cheie pregnancy, diabetes mellitus (DM), lipids. |
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