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618.3-06:616.8-009.24:612.015.11 (1) |
Științe medicale. Medicină (11196) |
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SM ISO690:2012 BOȘCĂNEANU (ARAPU), Natalia. The oxidative stress in preeclampsia. In: Moldovan Medical Journal, 2018, nr. 2(61), pp. 21-23. ISSN 2537-6373. DOI: https://doi.org/10.5281/zenodo.1299020 |
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Moldovan Medical Journal | |||||||
Numărul 2(61) / 2018 / ISSN 2537-6373 /ISSNe 2537-6381 | |||||||
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DOI:https://doi.org/10.5281/zenodo.1299020 | |||||||
CZU: 618.3-06:616.8-009.24:612.015.11 | |||||||
Pag. 21-23 | |||||||
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Background: The pathogenesis theories of preeclampsia include inappropriate trophoblast invasion and incomplete remodeling of spiral uterine arteries. This is followed by a reduced utero-placental perfusion; ischemia is the cause of oxidative stress activation. The imbalance between the oxidant and antioxidant components in favor of pro-oxidation, induce endothelium activation and / or dysfunction with the occurrence of clinical and laboratory manifestations. Material and methods: It was proposed a comparative prospective study including 105 pregnant women with preeclampsia in comparison with 367 pregnancies without preeclampsia. Pro-oxidant and antioxidant status and its correlation with systolic blood pressure values and classical laboratory marchers were analyzed. Results: In preeclampsia there is an excess accumulation of pro-oxidants comparing to control group p<0.001. Malondialdehyde and Advanced Oxidation Protein Products are most implicated in hypertensive syndrome r 0.7, p<0.001. Inflammatory diseases of uro-excretory tract accompanying preeclampsia, demonstrate excess accumulation of Advanced Oxidation Protein Products and AGE verprelizine-like and AGE pentozidine-like r 0.7, p<0.001. Modified ischemic albumin did not get the modified value in the research group. Conclusions: Excess accumulation of pro-oxidants in preeclampsia plays an important role in pathogenesis pathway, clinical and laboratory manifestation of preeclampsia |
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Cuvinte-cheie preeclampsia, oxidative stress, hypertension, proteinuria., pro-oxidants |
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