Neonatal acute kidney injury: predictive and diagnostic value of urinary protein biomarkers. 
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616.61-001-053.31-07 (1)
Patologia sistemului urogenital. Boli urinare şi sexuale (genitale) (392)
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BABINTSEVA, Anastasiya, AGAFONOVA, Lyudmila, KOSHURBA, Ilya, FRUNZA, Alina, BEVTSIK, Andriy. Neonatal acute kidney injury: predictive and diagnostic value of urinary protein biomarkers. . In: Buletin de Perinatologie, 2017, nr. 4(76), pp. 45-50. ISSN 1810-5289.
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Buletin de Perinatologie
Numărul 4(76) / 2017 / ISSN 1810-5289

Neonatal acute kidney injury: predictive and diagnostic value of urinary protein biomarkers. 

CZU: 616.61-001-053.31-07

Pag. 45-50

Babintseva Anastasiya, Agafonova Lyudmila, Koshurba Ilya, Frunza Alina, Bevtsik Andriy
 
Bukovinian State Medical University
 
 
Disponibil în IBN: 17 februarie 2018


Rezumat

1. A comprehensive clinical-paraclinical examination should be performed for timely diagnostics of AKI in critically ill term newborns with determination of early markers of renal dysfunction including urinary protein biomarkers. 2. Considering the values of AUROC the level of diagnostic value of the presented biomarkers concerning detection of AKI was determined: UIgG > Uα1-MG, UTPr > UAlb with absent diagnostic value of Uβ2-MG. 3. None of the presented diagnostic models demonstrated high discriminating ability with high values of Se and Sp at the same time concerning detection of AKI in critically ill newborns.

Cuvinte-cheie
term newborn, urinary concentration of total protein, urinary albumin, urinary immunoglobulin G, urinary α1-microglobulin, urinary β2-microglobulin, ROC-analyses.,

acute kidney injury