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Articolul precedent |
Articolul urmator |
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Ultima descărcare din IBN: 2018-08-02 14:23 |
Căutarea după subiecte similare conform CZU |
616-092-053.31 (1) |
Patologie. Medicină clinică (6994) |
SM ISO690:2012 HODOVANETS, Yulia, BABINTSEVA, Anastasiya. The status of the pro-oxidant system and antioxidant defense system in critically ill newborns: a preliminary study. In: Buletin de Perinatologie, 2015, nr. 2(66), pp. 52-59. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 2(66) / 2015 / ISSN 1810-5289 | ||||||
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CZU: 616-092-053.31 | ||||||
Pag. 52-59 | ||||||
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Rezumat | ||||||
Background and objectives: the objective of this research is to study the status of the pro-oxidant and antioxidant defense systems and relations between different components of these systems in critically ill newborns. Methods: the basic group of observation included 25 ill term neonates who had clinical symptoms of disorders on their fi rst week of life and received treatment in the Neonatal Intensive Care Unit. The control group included 37 apparently healthy term neonates. The study included detection of pro-oxidant system (oxidative modifi cation of proteins (OMP), malonodialdehyd (MDA)) and antioxidant defense system (ceruloplasmin (CP), catalase (CT), gamma-glutamyltranspeptidase (GGTP)) at 48-72 hours of life. Results: the obtained results showed that newborns from the basic group as compared to the children from control group had signifi cantly increased OMP and MDA levels and CP activity and signifi cantly increased CT and GGTP activities. The formation of qualitatively new relations between components of pro-oxidant and antioxidant systems and individual components in the middle of the antioxidant system in ill newborn was found in this study. Interpretation and conclusions: we concluded that term newborns who had clinical symptoms of disorders on their fi rst week of life demonstrated excessive activation of pro-oxidant processes, inadequate antioxidant protection and formation of new relations between components of these systems and individual components in the middle of the antioxidant system. The immature all systems and organs of these babies along with both intracellular oxygen free radical toxicity and extracellularly generated cytotoxic products of activated infl ammatory cells need special medical protection as a part of postnatal therapeutic care. |
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Cuvinte-cheie newborn, pro-oxidant system, ceruloplasmin, catalase, antioxidant defense system, oxidative modifi cation of proteins, malonodialdehyd, gamma-glutamyl transpeptidase |
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