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Ultima descărcare din IBN: 2024-01-28 15:40 |
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546.562:615.28:547.4 (1) |
Chimie anorganică (451) |
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Chimie organică (485) |
SM ISO690:2012 GRAUR, Vasilii О., GARBUZ, Olga, ZARICIUC, Elena, GUDUMAK, V., GULYA, Aurelian. Synthesis and biological activity of 2-formylpyridine n(4)-allyl-3-seleno-semicarbazone and its copper coordination compound. In: Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţele vieţii, 2015, nr. 3(327), pp. 135-142. ISSN 1857-064X. |
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Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţele vieţii | ||||||
Numărul 3(327) / 2015 / ISSN 1857-064X | ||||||
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CZU: 546.562:615.28:547.4 | ||||||
Pag. 135-142 | ||||||
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The paper presents the synthesis of the 2-formylpyridine N(4)-allyl-3-seleno-semicarbazone that was studied using NMR spectroscopy. This ligand was used for the synthesis of a copper(II) chloride coordination compound. The study of antimicrobial and antifungal activities showed that these substances possess bacteriostatic and bactericidal activities towards a series of gram-positive and gram-negative bacteria and fungi in the range of concentration 0.7-500μg/mL. The activity of the copper(II) coordination compound towards gram-negative microorganisms significantly exceeds the activity of the ligand. The antioxidant activity of the synthesized selenosemicarbazones exceeds the activity of the coordination compound. These substances inhibit proliferation of MeW-164, HL-60 and HeLa tumor cells. 16 references, 1 table, 7 schemes |
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Cuvinte-cheie selenosemicarbazones, copper complexes, Antimicrobial activity, antioxidant activity, antitumor activity |
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