The diagnosis, treatment, necessary resources, rehabilitations and prophylaxis of patients with mental and behavioral disorders in epilepsy (MBDE) are important issues for society. The authors have been studying MBDE for 20 years. The team of authors, assisted by means of artificial intelligence, researches the mechanisms of MBDE remissions in order to propose innovative methods of healing patients with MBDE. Some issues in the MBDE research field (RF) are at the frontier of knowledge. One of the authors, the psychiatristepileptologist Alexandru Popov, in 2003 had an experience of remission in approximately 100 patients with MBDE. Currently, doctor Alexandru Popov, assisted by the results of joint research, has achieved over 175 remissions in MBDE patients. Our research went through the following stages: 1. Description of the MBDE research field. RF MBDE operates with 27 MBDE diagnoses and a control diagnosis G40 (epilepsy without MBDE), 163 symptoms, associated with 17 syndromes. A book was developed [1], which includes 10 dimensions of MBDE and the MBDE Patients Support Guide. The work was appreciated with Diplomas of Excellence and Gold Medals at some International Research, Innovation and Book Fairs. 2. Formalization of RF MBDE knowledge. Inspired by Mendeleev’s Table, the authors developed two tables of 5040 cells each. Table data is organized hierarchically in three levels. The first table integrates fuzzy numerical data. The second table – fuzzy symbolic data corresponding to the first table. Both tables integrate data on the degree of manifestation of symptoms into syndromes and diagnoses. 3. Development of software and e-learning products for RF MBDE. 4. Development of 19 metric spaces for evaluating distances between MBDE RF diagnostics. 5. Development of 19 metric spaces for evaluating the similarities of RF MBDE diagnoses. An album of 76 MBDE distance and similarity evaluation tables was developed.