Introduction. Hyperuricemia (defined as a serum uric acid level >7 mg/dl in males and >6 mg/dl in women) is common in chronic kidney disease (CKD) as a result of reduced urinary excretion of uric acid and is considered as a risk factor for cardiovascular disease. Material and methods. We involved in the study 205 patients with CKD, 116 (56,9%)of them under chronic hemodialysis from Municipal Clinical Hospital Holy Trinity, 2019-2021. CKD was defined as abnormalities of kidney structure or function, present for >3 months, with implications for health. The kidney function were assessed by estimated glomerular filtration rate (eGFR). Results. The age average of the 205 patients was 62,06± 4,32, between them: male - 103(50,24%) and female - 102(49,75%). In the study group were revealed diabetes mellitus - in 179(83,32%), anemia in the 147(71,70%) and coronary heart disease in 124 (60,49%) cases. The average value of uric acid of the studied patients was increased: 9,15± 3,2 mg/dl, (median-7, 61 mg/dl, quartile 75% 10,38 mg/dl, quartile 25% - 6,55 mg/dl, lowest 3,50 mg/dl, highest - 15,67 mg/dl). Uric acid level was correlated with eGFR (r =−0,32; p<0,001) and with proteinuria (r= 0,12; p<0.001). There were 87 dead patients in the study group. Compared with survivors, the deceased patients had more increased value of uric acid and was estimated an association between the (≥75th) percentiles of uric acid and the patients mortality (p<0.001). Conclusion. Elevated serum uric acid levels are seen in patients with CKD and severe reduced glomerular filtration rate and was associated with all-cause mortality.