In the last decades there are noticed more oftenly negative climate changes and an increasing frequency of natural disrupting phenomenas both during the vegetation period of the plants and in the state of vegetative rest. This fact affects the normal develompent of grapevine plants, their vegetation process and as a result the grape harvest. The main goal of modern viticulture is to obtain high quality production with minimal resource consumption. And because of this, there is an urgent need to revive the viticultural assortment and to adapt it to the changing environmental conditions. With this purpose, after many years of selection and hibridation there where obtained interspecifical hybrids of Vitis Vinifera and Muscadinia Rotundifolia with a very high adaptation capability to abiotical factors and also tolerant to most grapevine pests and diseases. These genotypes are an appropriate response to the ever-increasing needs of modern viticulture and grapevine production. As object of study served interspecific rhizogenic grapevine genotypes with table grapes "Malena", "Nistreana" and "Algumax", as well as grapes for fresh consumption and processing: "Augustina", ”Alexandrina”, and ”Amethyst”. The respective genotypes are planted in the experimental grapevine sector of the institute. Based on the results of monitoring environmental factors, it was found that climate changes are amplifying at global level. The generator of these changes was and is the technical-economic progress of society. Climate changes require the creation of plant varieties that ensure performance in different production conditions. The current requirements of the wine sector is the creation of new varieties with stable productivity potential, high quality of grapes and wine products. As a result of crossing the genotypes of V. vinifera L. (2n=38) x M. rotundifolia Michx. (2n=40) were obtained and homologated interspecific rhizogenic grapevine genotypes with table grapes: "Malena", "Nistreană" and "Algumax" and with grapes for fresh consumption and for processing: "Augustina", "Alexandrina", "Sarmis" and "Ametist". This genotypes have a high genetical plasticity and therefore can be grown even in the Northern areas of the republic and also they are tolerant to the main grapevine pest Phyloxera Vastatrix. Because of the tolerancy to phylloxera the plants can be multiplied by cuttings without the need of all the complicated and expensive grafting process. The rhizogenic plants obtained have a very high adaptability and the derived products obtained are of high quality, and also rhizogenic vine plants have a longer exploitation life compared to plants obtained through the grafting process. The implementation of interspecific rhizogenic grapevine genotypes will contribute to the expansion of the grapevine cultivation limit towards the Northern area of the Republic of Moldova.The improvement of viticultural assortment can be achieved more easily with the cultivation of new interspecific, rhizogenic varieties, which show increased resistance to biotic and abiotic factors, including extreme climate factors.