The influence of γ-radiation on growth and lipids synthesis of on Streptomyces canosus 71 was studied. The strain was irradiated in four doses of γ-rays (1000 – 4000 Gy) and 12 new variants were selected. Three of them were stable in morphological properties and differed from the initial strain in the rate of biomass and lipids synthesis. The possibility of application the γ-irradiation for obtaining the new Streptomycetes strains, producing the biologically active sustances (lipids) was shown.