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SM ISO690:2012 CRACEA (DRUŞCA), Angela, REVENCO, Ninel. Le rôle de la catalase et de la céruloplasmine dans la pathogenèse de l’arthrite juvénile idiopathique
. In: Buletin de Perinatologie, 2012, nr. 3, pp. 17-22. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 3 / 2012 / ISSN 1810-5289 | ||||||
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Pag. 17-22 | ||||||
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Introduction. The pathogenesis of juvenile idiopathic arthritis (JIA) is complex, in a permanent study. The oxidative
stress has an important part in the perpetuating of infl ammatory response. The antioxidant barrier is a complicated system
of enzymes, elements and substances that are formed to protect the aerobic organisms against high concentrations
of oxygen. A marker of the antioxidant system is catalase. Catalase is an enzyme that breaks down hydrogen peroxide
into water and molecular oxygen. Activity of catalase in cells is very important. Another component of the antioxidant
system is ceruloplasmin. Ceruloplasmin is a polyfunctional protein, is an extracellular antioxidant enzyme.
Material and methods. 150 children with JIA and 20 real healthy children were included in a randomized study.
The study involved 98 boys (65,3%) and 52 girls (34,7%) aged between 18 and 221 months (mean 134,22±4,71 months).
Disease duration was from 1,0 month to 198,0 months (mean 36,19±3,22 months). Time addressing the rheumatologist
after the onset of disease was from 1,0 month to 72,0 months (mean 6,01±0,86 months). The distribution depending on
the clinical form was as follows: oligoarticular form – 61 (40,7%) children, polyarticular form – 59 (39,3%) children,
systemic form – 18 (12,0%) children, arthritis with entesits – 9 (6,0%) children, psoriatic arthritis – 2 (1,3%) children
and others arthritis – 1 (0,7%) child.The authors appreciated the indices of the antioxidant system (catalase and ceruloplasmin)
at 90 patients with JIA and 20 healthy children.
Results obtained. A low endogenous antioxidant capacity was registered in JIA and the functionals parameters of
catalase were found much lower at the patients with JIA, compared with the control group. Have noted higher values of
catalase in oligoarticular and polyarticular forms versus systemic form (p<0,05). Ceruloplasmin noted a trend towards
values in oligoarticular and polyarticular forms compared with the systemic form (p> 0,05). The values of catalase were
found to be lower for disease duration up to 6 months and higher for disease duration exceeding 24 months. The study
of ceruloplasmin showed lower values for disease duration exceeding 24 months compared with disease duration up to 6
months. Catalase and ceruloplasmin were investigated by functional class (FC) after Steinbrocker. We noted higher values
of catalase for FC I, II compared with FC III, IV (p>0,05). Research ceruloplasmin determined higher values for FC III, IV
and lower values for FC I, II (p>0,05). Catalase and ceruloplasmin were studied by radiological stage after Steinbrocker.
Catalase noted practically the same values for radiologicals stages I, II and for radiologicals stages III, IV (p>0,05).
Ceruloplasmin had higher values in radiologicals stages III, IV and lower in radiologicals stages I, II (p> 0,05).
Conclusions. Endogenous antioxidant capacity is low in JIA, characterized by low levels of catalase and ceruloplasmin.
Catalase and ceruloplasmin resulted in much lower values in systemic arthritis compared with oligoarticular
and polyarticular forms, refl ecting a capacity of endogenous antioxidant protection than lower in systemic arthritis
compared with the others variants of JIA. Depending on the duration of the disease, ceruloplasmin showed higher values
for disease duration up to 6 months compared with disease duration exceeding 24 months, which shows a higher
endogenous antioxidant capacity during early JIA background of an intensity high oxidative processes specifi c to this
stage of the disease. Catalase found lower values for functionals classes III, IV by Steinbrocker. |
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Cuvinte-cheie Juvenile idiopathic arthritis, oxidative stress, antioxidant system |
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