This paper focuses on the study of the effect of extraction solvent choice on phenolic compounds contents and antioxidant activity of Bassia muricata. In this study, five different solvents namely: water, acetone, ethanol, methanol and hexane, and three extraction techniques were used to extract phenolic compounds: microwave-assisted extraction, Soxhlet and maceration. Total phenolics (TPC), total flavonoids (TFC) and condensed tannins contents (CTC) were determined. The results showed that different solvents with different polarity had a major effect on polyphenolic contents and antioxidant activity; the highest TPC (122.15-144.82 mg GAE/g), TFC (64.12-70.32 mg QE/g) and CTC (30.38-36.09 mg CE/g) were obtained with methanol. However, different extraction methods gave comparable results. In vitro antioxidant activities were evaluated using the DPPH radical scavenging ability, reducing capacity and β-carotene bleaching assay. The methanolic extract showed the highest scavenging abilities on DPPH radicals and lipid peroxidation, while the aqueous extract exhibited the strongest reducing power. Microwave-assisted extraction was the best suited for the extraction of antioxidant molecules when compared to Soxhlet and maceration.