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618.39-06:616.151.5 (1) |
Științe medicale. Medicină (11192) |
Patologia sistemului circulator, a vaselor sanguine. Tulburări cardiovasculare (978) |
SM ISO690:2012 MITRIUC, Diana, POPUŞOI, Olga, CATRINICI, Rodica, FRIPTU, Valentin. Pierderea recurentă a sarcinii și trombofilia. In: Buletin de Perinatologie, 2018, nr. 5(81), pp. 77-82. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 5(81) / 2018 / ISSN 1810-5289 | ||||||
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CZU: 618.39-06:616.151.5 | ||||||
Pag. 77-82 | ||||||
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It has been confi rmed that APS is the only acquired thrombophilia associated with RPL and other adverse outcomes of pregnancy. The quality of research and elaborate methodology in most of the studies about the association of hereditary thrombophilia and RPL are lacking. They are mostly limited to small observational studies with limited and heterogeneous samples. The analyzed studies generally suggest that the presence of a congenital thrombophilia in pregnant women is associated with late pregnancy loss or stillbirth, but not with an increased risk of early pregnancy loss. One possible explanation is that late pregnancy loss refl ects placental vessel thrombosis, compared to fi rst trimester losses that are more commonly caused by other causes. Thrombophilic defects also increase the risk of early pregnancy loss in the fi rst trimester of pregnancy. However, these eff ects may vary across populations. The defi nition and classifi cation of RPL, the eff ect of congenital thrombophilias on spontaneous abortions requires additional studies. A combination of risk factors (pregnancy, multiple hereditary thrombophilic defects) is associated with the secondary hypercoagulable states and has a strong association with pregnancy complications. Women with AT defi ciency or combined thrombophilic defects (including the homozygous FVL G1691A gene mutation, the homozygous prothrombin G20210A gene mutation and combined heterozygosities) or with additional risk factors should be monitored in order to supervise the pregnancy evolution and to decide on the need for thromboprophylaxis during the pregnancy. |
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