Au fost investigate 124 de femei cu depresie nonpsihotică cu vârsta între 18-45 de ani. La 95 dintre pacienţi (grup de studiu), depresia se asocia cu un nivel crescut de anxietate trăsătură sau/şi stare. Lotul de control l-au constituit 29 de bolnavi la care nivelul de anxietate nu depăşea limita fi ziologică. Utilizând un chestionarelaborat special şi calculând coefi cienţii de corelare, a fost studiat impactul diferitor factori de risc semnifi cativi în sensul declanşării depresiei la persoanele cu nivel crescut de anxietate. Au fost evaluaţi coefi cienţii efi cacităţii tratamentului cu antidepresive triciclice şi inhibitori selectivi ai recaptării de serotonină la această categorie de pacienţi. Au fost evidenţiate particularităţile clinico-evolutive ale depresiei în funcţie de tipul anxietăţii: la pacienţii cu nivel crescut de anxietate trăsătura depresia evolua lent, severitatea ei corela direct cu intensitatea anxietăţii, în tabloul clinic predominau simptomele afective fără fl uctuaţii nictemerale evidente, manifestând tendinţe de recurenţă şi cronicizare. Depresia asociată cu anxietate situativă debuta acut, simptomele afective se interferau frecvent cu tulburări vegetative, în tabloul clinic erau prezente ideaţia autolitică şi agitaţia psihomotorie. Evoluţia depresiei corela direct cu evoluţia situaţiei stresogene; când depresia evolua pe fundal de anxietate, stare şi trăsătură manifestate în egală măsură, debutul a fost brusc, cauzat adeseori de situaţii stresogene nesemnifi cative, tabloul clinic a fost polimorf, episoadele depresive fi ind severe cu tendinţe de recurenţă. Tulburările vegetative, mai frecvent sub aspect de simpaticotonie şi dissomniile, au fost simptome comune tuturor pacienţilor investigaţi. Tratamentul depresiei la persoanele cu nivel crescut de anxietate trebuie să fi e complex (psihoterapeutic şi farmacoterapeutic) şi de durată, cu utilizarea obligatorie a remediilor antidepresive cu efect anxiolitic.

There were investigated 124 of women from 18 to 45 years, suffering from a non-psychotic depression. For 95 patients (basic group), the depression has been accompanied with an increased level of the personal and/or reactive anxiety. 29 patients, with the anxiety level within the physiologically acceptable limits, formed a control group. By applying the specially elaborated questionnaire and by establishing the correlation coefficients, the factors contributing to the development of depression at the persons with an increased level of anxiety have been studied. The coefficients of tricycles antidepressants and selective serotonin recapture inhibitors efficiency, for this category of patients, have been studied. The particularities of the depression clinics and course, depending on the type of anxiety, were established: for the persons with an increased level of the personal anxiety, the depression was developing gradually, its severity was correlating in a positive way with the anxiety level, in the clinical picture, the affective symptomatology without any wide daily oscillations was prevailing, having tendencies to a chronic course and incomplete remissions; the depression against the background of a reactive anxiety was characterizing with an acute beginning, in the clinical picture, somatic-vegetative and affective symptoms were observed, the suicidal thoughts, the psychomotor agitation was present; its evolution was depending on the stressogenic situation dynamics, while the personal and reactive anxiety was declaring itself to the same extent, the depressions were evolving acutely, even after non-considerable stresses, the clinic polymorphism, the grave depressive episodes with a tendency to the recidivism were prevailing. The vegetative dysfunctions, more often in the form of the sympathicotonia and sleep disturbance were present at the most examined patients. The treatment of the depression, for anxious persons, must be complex (psychotherapeutic and pharmacologic) and log-term, and must include obligatory the antidepressants with an anti-anxiety effect.