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SM ISO690:2012 MĂTRĂGUNĂ, Nelea, COJOCARI, Svetlana, BICHIR-THOREAC, Liliana. Rolul factorilor de risc prenatali, a homocisteinei şi vitaminei D în realizarea hipertensiunii arteriale la copii.. In: Buletin de Perinatologie, 2018, nr. 4(80), pp. 34-42. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 4(80) / 2018 / ISSN 1810-5289 | ||||||
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CZU: 616.12-005-02-053.2:577.112.386 | ||||||
Pag. 34-42 | ||||||
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Theme topicality. In the recent decade, besides the genetic, antenatal and traditional risk factors researches have been focused on the identification of the new risk factors of AHT in children such as hypovitaminosis D and hyperhomocysteinemia that will identify AHT at the preclinical stage. The material and methods. The investigation made is of type – case-control and included 115 hypertensive children, aged 10-18, that were divided in the following way: group I - 35 hypertensive children with normal weight (AHT, NW), group II - 36 hypertensive children with overweight (AHT, OW), and group III - 44 hypertensive children with obesity (AHT, OB). Control group included 35 children with normal tension and weight (N, N) of the similar age. Homocysteine (Hcy) was appreciated through the liquid chromatography with ion exchange, but 25-OH –vitamin D was determined through immunochemistry chemiluminescence detection (CLIA) Results. Out of prenatal risk factors the following were of significant importance: alimentation errors in pregnant women, physical development during the fi rst year and duration of natural alimentation. There was revealed a lower serum level of 25 (OH) vit D (AHT, OB - 21,9 ±3,79 ng /ml); AHT, OW- 20,5±0,96 ng / ml); AHT, NW -26,37±1,06 vs NN-32,22±0,48 ng /ml), but increased one of Hcy (AHT, OB-26,5±3,41 μmol/L; AHT, OW-13,1±2,63 μmol/L; AHT, NW -8,2±0,54 vs NN-6,1±0,23 μmol/L) in all the investigated groups as compared to control group. But the lowest level of 25 (OH) vit D and the highest one of Hcy was stated at children where AHT was associated with obesity or over weight. Conclusions. The results of the research show that hypovitaminosis D and hyperhomocysteinemia are the risk factors for the AHT as well as for the overweight. Prevention of the development of these pathologies must start during the pregnancy. Additional investigations are necessary to complete these statements as well as correction of vitamin D deficiency from the point of view on cardio vascular health. |
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Cuvinte-cheie children, risk factors, arterial hypertension, homocysteine, vitamin D |
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