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Ultima descărcare din IBN: 2024-01-29 15:40 |
SM ISO690:2012 MOŞIN, Veaceslav, HOTINEANU, Alina, CREŢU, Adrian, SCURTU, Vitalie, HOLBAN, Iuliana. Hiperhomocisteinemia şi patologia reproductive. In: Buletin de Perinatologie, 2014, nr. 1(61), pp. 40-46. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 1(61) / 2014 / ISSN 1810-5289 | ||||||
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Pag. 40-46 | ||||||
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Hyperhomocysteinemia defines the state in which concentrations of the non-protein forming amino acid homocysteine exceeds normal level. Mutations in the genes of folic acid cycle (MTHFR, MTR, MTRR) togheter with decreased intake of vitamins of B group involved in homocysteine metabolism have a great contribution to hyperhomocysteinemia. Elevated concentration of homocysteine is toxic for the blood vessels and can initiate a cascade of vascular complications, including thrombosis. At the moment, hyperhomocysteinemia may be associated with adverse events during pregnancy: placental abruption, preeclampsia, neural tube defects, intrauterine growth retardation. Genetic testing for patients allows to predict the risk of hyperhomocysteinemia and thrombotic events, indicate an appropriate treatment and monitor evolution of pregnancy. |
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Cuvinte-cheie hyperhomocysteinemia, MTR, MTRR, spontaneous miscarriages, thrombophilia., MTHFR |
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