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616.34-008.1-036.22-053.2(478) (1) |
Patologia sistemului digestiv. Tulburări ale tubului alimentar (1746) |
SM ISO690:2012 CLICHICI, Diana. Epidemiological aspects of celiac disease in children in the Republic Moldova. In: Buletin de Perinatologie, 2015, nr. 4(68), pp. 39-42. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 4(68) / 2015 / ISSN 1810-5289 | ||||||
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CZU: 616.34-008.1-036.22-053.2(478) | ||||||
Pag. 39-42 | ||||||
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Last decades are characterized not only by increased morbidity indices of celiac disease in some countries, but also by change of the evolving nature of the disease with prevalence of atypical forms. Improving diagnostic criteria of celiac disease over the past three decades has led to increased global incidence of this disorder. There is still a lack of national data on epidemiological peculiarities of celiac disease in the Republic of Moldova. The purpose of this article was to perform a retro- and prospective study to assess the share of celiac disease among the pediatric population requiring specialized medical care. Material and methods. The research was based on a retro- and prospective study that has included all patients with intestinal malabsorption, 835 children admitted to Gastroenterology Department, PMSI Institute of Mother and Child during 2010-2014. 62 children were confirmed to have celiac disease following history taking, clinical examination, serological examination (transglutaminase tTG IgA and IgG antibodies), endoscopic and histological exam. Results. The study was based on research of 62 children with celiac disease, aged between 2 and 17 years, with a mean age of 7.79 ± 0.14 years. Atypical form of the disease was determined in 61.29% (39 children), typical form # 32.5 (20 children), silent in 3.22% (2 children), latent 1.61% (1 child). Conclusion. Celiac disease is a health problem affecting more and more pediatric population. To identify trends in the natural evolution of celiac disease and its impact on quality of life it is necessary to actively introduce new approaches to early diagnosis of this disease which would allow a correct and early therapeutic conduct to ensure harmonious development of the child. Background. Celiac disease is a disorder of the small intestine caused by intolerance to gluten and related proteins in genetically susceptible people. It is a disorder whose prevalence has increased greatly in recent decades, globally estimated at 0.5% -1%. |
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Cuvinte-cheie Celiac disease, prevalence, epidemiology. |
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