Transition to a more sustainable agriculture in the Republic of Moldova is the main issue discussed in the article. The discrepancy between prices for industrial inputs and prices for agricultural products is making the economic existence of farmers and rural communities more complicated. In order to decrease the dependence of farms from industrial inputs (mineral fertilizers, especially nitrogen, pesticides etc.) a system approach to farm management is proposed, including: land organization, according the landscape particularities; respecting of crop rotation with a higher diversity of the main and successive crops; integration of animal and crop husbandries; cooperation between producers and factories for processing of agricultural products etc. By respecting agroecological principles it would be possible for farmers to provide ecosystem services, which should be stimulated by the society.