Cytokine levels in experimental hemorrhagic shock associated with acute ethanolism before and after resuscitation with Dextran 70 and Raviten (Difetur) Administering the combination of colloid Dextran 70 solution with concomitant NOSinhibitor Raviten (Difetur) to shocked animals with ethanol intoxication showed lowering of serum pro-inflammatory cytokines (IL-1; IL-6 and TNF-α) with considerable increase of IL-10 level (anti-inflammatory cytokine), phenomenon that would contribute to the reduction of systemic cellular injuries. Pathogenetic therapy of experimental hemorrhagic shock with ethanol intoxication consisting of Dextran and Difetur has resulted in decreased serum levels of proinflammatory cytokines, increased levels of anti-inflammatory cytokines, which confirms the opportunity of supplementing the basic therapy with NOS inhibitors.

Administrarea combinaţiei soluţiei coloidale Dextran 70 concomitent cu inhibitorul NOSRaviten (Difetur) animalelor şocate pe fondal de alcoolemie a atestat reducerea veridică în serul sanguin a nivelului citokinelor proinflamatoare (IL-1; IL-6 şi TNFα) cu creşterea considerabilă a nivelului IL-10 (citokină antiinflamatoare) fenomen ce ar contribui la reducerea leziunilor celulare sistemice. Tratamentul patogenetic al ŞH experimental pe fondal de alcoolemie cu Dextran şi Difetur a determinat reducerea nivelului de citokine proinflamatoare, creşterea nivelului citokinelor antiinflamatoare ceea ce confirmă oportunitatea suplinirii tratamentului de bază cu inhibitori ai NOS.