Statistical analysis of the uncultured synanthropic flora described during XIX – XXI centuries contains a number of 731 species. A considerable increase of annual and biannual species was observed during this time. Dynamics of ecological indices values indicates the increase of xeromesophiles (U2) with 83 species, mezophiles (U3) with 74 species. It has been established that the number of moderate thermophiles (T4) increases with 99 species, mesothermal moderate ther-mophiles (T3,5) with 51 species depending on the temperature. The number of amphytolerant species (Ro) increases with 107 species, and the number of weak acid-neutrophiles (Rn) – with 97 species depending on the soil reaction. According to the analysis of the dynamics of phytogeographic elements it has been established that Eurasian element prevails, followed by southern elements (Medit Pont Balc Carp.). The number of cosmopolitan species increases conside-rably with 31 taxa and of those adventives with 189 taxa which confirms the high synanthropic level of the Republic of Moldova flora.