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SM ISO690:2012 ŞESTACOVA, Cristina, DIUG, Eugen, CIOBANU, Nicolae, GURANDA, Diana, CIOBANU, Cristina. Polymeric micelles as a promising system in increasing the bioavailability of poorly watersoluble drugs. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 476. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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Pag. 476-476 | ||||||
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Background. Some medicinal substances, due to their low solubility in water, are limited in absorption. Polymeric micelles (PMs) have great potential as a drug delivery system for compounds that are hydrophobic and have poor bioavailability. Objective of the study. Description of PM as nanosystems capable of increasing the bioavailability of sparingly soluble drugs. Material and Methods. The main sources of information on the structure, classification, formulation, and mechanisms involved in improving the absorption of associated medicines in MP were selected (Scopus, PubMed). Results. PMs are nanostructures consisting of block-amphiphilic copolymers. The inner hydrophobic core allows the incorporation of water-insoluble drugs. There are features of PM that allow them to cross the epithelium. PM in the form of nanoparticles easily crosses the intestinal barrier. In order to obtain good bioavailability, the drugs can be administered in a certain region of the gastrointestinal tract, for which PM can be manipulated by coupling different types of polymers or by grafting different functional groups to the hydrophilic end of the copolymer, such as groups pH sensitive and receptor sensitive. Conclusion. Thus, PMs are a very promising nanosystem in order to improve the bioavailability of the oral drug due to the special stability that facilitates the safe transport of PMs through the gastrointestinal tract. |
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Cuvinte-cheie Polymeric micelles, nanosystems, solubilization, Micele polimerice, nanosisteme, solubilizare |
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