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Ultima descărcare din IBN: 2023-06-26 20:22 |
Căutarea după subiecte similare conform CZU |
616.24-002.5-092:577.1 (2) |
Patologia sistemului respirator. Tulburări ale organelor de respiraţie (760) |
Bazele materiale ale vieții. Biochimie. Biologie moleculară. Biofizică (667) |
SM ISO690:2012 NIGULYANU, Adriana, LESNIK, Evelina, PRIVALOV, Elena. Pathogenetic diversity of the immune disturbances in patients with pulmonary drug susceptible and drug resistant tuberculosis. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 247. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.24-002.5-092:577.1 | ||||||
Pag. 247-247 | ||||||
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Background. The immune response to M. tuberculosis infection consists mainly in the activation of the cell-mediated immune response (CIR). Natural resistance (NR) and humoral immunity (HI) contribute to a long-lasting immune resistance to reinfection and reactivation of latent infection. Objective of the study. Assessment of the pathogenic diversity of immune disorders (ID) in serum in patients with pulmonary susceptible tuberculosis (S-TB) and MDR-TB. Material and Methods. Indicators of CIR (CD3+), NR (phagocytic number), and HI (CD19 +) were determined in 36 healthy individuals (control group-CG), 57 new cases with S-TB (study group 1-SG1) and 72 new cases of MDR-TB (study group 2-SG2). The average was reported to the CG, which was the reference value, %. Range 1-33% of the reference value in CG considered the 1st degree of ID, 34-66% - the 2nd degree ID, >66% - the 3rd degree ID, as positive-immune overactivity (IOA) and negative-immune deficiency (ID). Results. Indices of CIR showed in the SG1 the cell-mediated immune deficiencies (CID) in 41% cases all of the 1st degree ID, in the SG2- CID of the 1st degree was in 82% and of 2nd degree CID - in 18% of cases. In the SG1 the CID was established in 91% and HI deficiencies (HID) – in 9%. In the SG2 the CID was in 90%, HID in 10% and NR deficiencies (NRD) in 23% of cases. SG1 the 1st degree IOA was detected in 43%, 2nd degree 31% and 3rd degree 26% cases. In SG2 the 1st degree IOA was established in 16%, 2nd degree in 36% and 3rd degree in 53% of cases. Conclusion. The deficiencies of the CIR were more frequently, established in patients with MDR-TB, associated with a higher rate of NRD and HID and a higher degree of IOA. |
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Cuvinte-cheie tuberculosis, cell-mediated immune response, natural resistance, humoral immunity, tuberculoza, răspunsul imun mediat celular, rezistenţa naturală, imunitatea umorală |
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