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Ultima descărcare din IBN: 2023-06-07 01:51 |
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616.24-002.5-092:577.1 (2) |
Patologia sistemului respirator. Tulburări ale organelor de respiraţie (760) |
Bazele materiale ale vieții. Biochimie. Biologie moleculară. Biofizică (667) |
SM ISO690:2012 LESNIK, Evelina, PANTEA, Valeriana. Disturbances of the antioxidant system in patients with pulmonary drug susceptible and multidrugresistant tuberculosis. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 242. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.24-002.5-092:577.1 | ||||||
Pag. 242-242 | ||||||
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Background. Biomarkers of thiol-disulfide metabolism (TDM) reflect the deficiencies of the antioxidant system (AOS) and the protective mechanisms against the oxidative stress (OS). Objective of the study. Assessment of the disturbances of the activity of the TDM enzymes in the peripheral blood serum (PBS) in patients with susceptible TB and MDR-TB. Material and Methods. Were measured the biomarkers of the TDM: level of total glutathione (tGSH), reduced glutathione (rGSH), oxidized glutathione (GSSG), rate rGSH/GSSG, activity of glutathione enzymes: glutathionereductase (GR), glutathione-peroxidase (GPO), glutathionS-transferase (GST), γ-glutamyl transpeptidase (γ-GTP) in 36 healthy (control group-CG), 54 new cases with susceptible TB (1st study group-1st SG and 56 new cases with MDR-TB. Statistical analysis was performed by SPSS Statistics 23.0 in which the Mann-Whitney U test was calculated, mean was reported to CG and expressed in %. Results. Level of tGSH was statistically lower in both SG (1st SG and 2nd SG) compared with SG, lower in 1st SG (80%) and 2nd SG (85%), p < 0.01; rGSH was moderately lower in both SGs. Concentration of GSSG was statistically diminished in SGs, lower in 1stSG (30%) vs. 2ndSG (25%), p < 0.01. The rate rGSH/GSSG was higher in 1stSG (1.19) vs. 2ndSG (1.15). GST activity was decreased in 1stSG (33%) and increased in 2ndSG (30%). GR was moderately increased in both SGs. GPO was moderately increased in 1stSG (20%) and 2ndSG (11%). γ-GTP was increased in 2ndSG (83%) vs. 1stSG (47%), p < 0.01. Conclusion. In TB were established important deficiencies of TDM, which permit development of programs for precocious diagnosis, prevention of complications and improvement of treatment. |
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Cuvinte-cheie tuberculosis, oxidative stress, thiol-disulfide metabolism, tuberculoza, stres oxidativ, metabolismul tioldisulfidic |
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