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Ultima descărcare din IBN: 2024-02-13 23:55 |
Căutarea după subiecte similare conform CZU |
616.126-002-022-07-085 (2) |
Patologia sistemului circulator, a vaselor sanguine. Tulburări cardiovasculare (978) |
SM ISO690:2012 DUMITRAȘCO, Ana-Maria, BULMAGĂ, Daniela, DUMITRAS, Mariana, GRIB, Carolina, SPATARI, Anastasia, RUSU, Adriana. The peculiarities of fungal infective endocarditis . In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 172. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.126-002-022-07-085 | ||||||
Pag. 172-172 | ||||||
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Introduction. Fungal infective endocarditis (FIE) is a rare and fatal pathological condition being the most serious form of infective endocarditis (IE), with a high mortality rate of 50% and being diagnosed postmortem. Objective of the study. To study the evolution of fungal infective endocarditis in patients in the Republic of Moldova and to apply the results to select the appropriate treatment tactics. Materials and methods. The prospective-retrospective study included 105 patients with defined FIE from Republic of Moldova, during the years 2011-2022, and the results were processed by statistical methods and compared with data from modern literature. Results. Fungal infective endocarditis was detected in 14.3%. The predominant etiology was Candida albicans 66.7% and Aspergillus spp. 20%. The incidence of men prevailed 73.3% vs 26.7% in women, with ratio of 2.7:1. Among the risk factors that favored the development of FIE we mention: valve prostheses 33.3%, respiratory infectious 46.6% and intravenous drug use 33.3%; the main comorbidities being chronic kidney disease and HIV AIDS. The tricuspid valve was the most affected 46.6%. Heart failure developed exclusively, and embolism in 53.3%, the most common being of the extremities. Mortality in the group with FIE was 20.2%. Conclusions. Fungal infective endocarditis is frequently caused by Candida albicans and Aspergillus spp., treatment requires the combination of 3-4 antibiotics and 2 antifungal drugs. High mortality is determined by the difficulties of diagnosis and severe complications. |
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Cuvinte-cheie fungal infective endocarditis, valve prostheses, mortality, endocardita infecțioasă fungică, proteze valvulare, mortalitate |
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