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616.24-002-006.5-036.12:616.12-008.46 (1) |
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SM ISO690:2012 CAȘCAVAL, Virginia, FETCO-MEREUŢĂ, Diana, GRIB, Liviu, PANTEA, Valeriana, ANDRONACHE, Lilia, DUMITRAŞ, Grigorie. Comparison of oxidative stress parameters in patients with community-acquired pneumonia depending on heart failure severity. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 171. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.24-002-006.5-036.12:616.12-008.46 | ||||||
Pag. 171-171 | ||||||
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Background. At the present time, the alternation of the oxidative metabolism is considered as one of the leading pathogenic mechanisms in community-acquired pneumonia (CAP). However, the direction of the oxidative stress markers changes in patients with CAP and preexistent heart failure (HF) had been almost unexplored. Objective of the study. To compare the changes of oxidative stress biomarkers levels in patients with CAP depending on HF severity. Materials and Methods. Plasma levels of oxidative stress markers were studied in 77 patients. In study were included 31 men (30.3%) and 46 women (59.7%), with the mean age of 68.6 ± 8.01 years. Patients were divided into two groups, according to HF severity: group 1 (n = 42) – patients with CAP associated with HF, NYHA stage II, group 2 (n = 35) – patients with CAP associated with HF, NYHA stage III. The levels of ischemic modified albumin (IMA), advanced glycation end products (AGE), catalase, malondialdehyde (MDA) and superoxide dismutase (SOD) were compared in both groups. Results. IMA levels were increased in group 2 compared to group 1: 212 ± 54.3 μM/L (95% CI 231-99) vs. 189 ± 58.2 μM/L (95% CI 171-207), p > 0.05. MDA and SOD were without significant changes in both groups. Catalase levels were higher in patients with HF, NYHA stage III: 18.2 ± 6.0 μM/L (95% CI 16-20) vs. 15.1 ± 5.3 μM/L (95% CI 13-16), p < 0.05. AGE products were higher in patients with CAP and advanced HF (group 2) compared to group 1: 633 ± 301.4 μM/L (95% CI 530-757) vs. 459 ± 181.7 μM/L (95% CI 403516), p < 0.05. Conclusion. The oxidant/antioxidant imbalance status plays an important role in development and progression of CAP in patients with preexistent HF. |
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Cuvinte-cheie Oxidative stress markers, community-acquired pneumonia, heart failure, Markeri ai stresului oxidativ, pneumonie comunitară, insuficienţă cardiacă |
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