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Ultima descărcare din IBN: 2023-12-12 12:48 |
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615.281/282.015.8+616.992 (2) |
Farmacologie. Terapeutică. Toxicologie (1598) |
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SM ISO690:2012 IAZAJII, Cristian. Antifungal resistance and enzymatic factors of pathogenicity of clinical strains of Candida albicans. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 123. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 615.281/282.015.8+616.992 | ||||||
Pag. 123-123 | ||||||
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Background. Candida is found as normal flora in healthy individuals and are involved in the etiology of opportunistic infections with high mortality rates, especially in immunocompromised individuals. Species of this genus are the fungi that are most frequently involved in human pathology due to their virulence factors and their ability to develop antifungal resistance. Objective of the study. Elucidation of antifungal resistance and enzymatic factors of pathogenicity of clinical strains of Candida albicans. Material and Methods. 87 C. albicans strains isolated from various clinical biosubstrates were examined and identified by standard microbiological techniques. Antifungal susceptibility testing was performed according to EUCAST methodology (The European Committee on Antimicrobial Susceptibility Testing) by quantitative methods with the determination of the minimum inhibitory concentration (E-test, Vitek 2 Compact). The determination of enzymes’ pathogenicity was performed according to up-to-date methodology. Results. The C. albicans strains studied showed different levels of sensitivity to the tested antifungals. The highest levels of resistance were to miconazole (52.2%) and itraconazole (34.6%). C. albicans strains are susceptible to ketoconazole (91.8%) and flucitosin (89.6%). When studying the pathogenic enzymes, it was found that 65.2% of the strains showed lipolytic activity and 73.5% - hemolytic activity. Conclusion. The results of the study show a high rate of resistance to some antifungal drugs of clinical strains of C. albicans. Proteolytic enzymes and hemolysins, important pathogenic factors responsible for the invasion and destruction of host tissues have been identified in over 60% of strains. |
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Cuvinte-cheie Candida albicans, antifungal resistance, pathogenic enzymes, Candida albicans, rezistenţă la antifungice, enzime de patogenitate |
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