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SM ISO690:2012 PANTEA, Valeriana, LESNIK, Evelina, POPA, Veaceslav. In vitro action of some coordinative compounds, thiosemicarbazide derivatives on the thiol-disulfidic system. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 44. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 547.497:61:57.085 | ||||||
Pag. 44-44 | ||||||
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Introduction. Currently, there is a growing interest in the new coordinating compounds of thiosemicarbazide (CCT) due to their pronounced antitumor and antiproliferative action, but their influence on the cellular thiol-disulfide metabolism (TDM) has not been studied. The aim of the study was to evaluate the impact of CCT on TDM indices in peripheral blood supernatant (PBS) in in vitro experiments. Material and methods. The action of CCTs – coded compounds CMA-18 (C1), CMC-34 (C2), CMD-8 (C3), CMG-41, (C4) and CMJ-33 (C5) on the TDM biomarkers -total glutathione level (tGSH), reduced glutathione (rGSH), oxidized glutathione (GSSG) and glutathione enzymes - glutathionereductase (GR), glutathione-peroxidase (GPO), glutathioneS-transferase (GST) and γ-glutamyl transpeptidase (γ-GTP) were evaluated in PBS. Results. The concentration of tGSH decreased under the influence of C1 and C2; rGSH decreased under the influence of C1 and increased under the influence of C3, C4, C5; the GSSG decreased under the influence of all CCTs; GST increased under the influence of C3 and C5; GPO decreased under the influence of C1 and increased under the influence of C3; GR decreased under the influence of C1, C2, C3, C4; γ-GTP increased (2 - 4 times) under the influence of all CCTs. Conclusions. The obtained results obtained data are essential for the development of effective strategies for the treatment of multifactorial diseases, including neoplastic diseases. |
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Cuvinte-cheie thiosemicarbazide coordinating compounds, thiol-disulfide metabolism, peripheral blood supernatant, compuși coordinativi ai tiosemicarbazidei, metabolism tiol-disulfidic, supernatantul sângelui periferic. |
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