Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
287 9 |
Ultima descărcare din IBN: 2023-11-30 22:12 |
Căutarea după subiecte similare conform CZU |
616-056.25:575.13 (1) |
Patologie. Medicină clinică (6999) |
Genetică generală. Citogenetică generală (429) |
SM ISO690:2012 ANDRIUȚĂ, Carolina. Molecular-genetic aspects of obesity. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 16. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616-056.25:575.13 | ||||||
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Background. Obesity is a metabolic disease, with a multifactorial origin, characterized by an increase in adipose tissue and an excess of weight greater than 25% compared to normal values in regards of age and sex. Along with exogenous and endogenous factors involved in weight control, predisposing genetic factors play a key role in the development of this disease. Objective of study. Researching the molecular-genetic aspects and the risk factors in the development of obesity. Material and Methods. Data from specialized articles from PubMed, Google Scholar and Hinari databases has been used. Results. Analyzing the bibliographic data, the leptin-melanocortin pathway has been found to play a major role in the development of obesity through mutations in POMC, AGRP and MC4R genes. Neurons that express POMC at the arcuate nucleus of the hypothalamus interact with MC4R neurons in the paraventricular nucleus, where melanocortin peptides act by decreasing food intake. On the other hand, AGRP in the arcuate nucleus acts by antagonizing the actions on MC4R, thus resulting in an increase in food intake. AGRP and POMC neurons are sensible to leptin levels in the body, which act through the LEPR receptors. Mutations in any gene responsible for the leptinmelanocortin pathway result in hyperphagia and severe obesity. Conclusion. The role of genetic factors cannot be neglected in the pathogenesis of obesity. The molecular-genetic diagnosis of a patient could considerably improve the development of strategies for the prevention and personalized treatment of obesity. |
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Cuvinte-cheie obesity, POMC, AGRP, MC4R, LEPR, leptin-melanocortin pathway, obezitate, POMC, AGRP, MC4R, LEPR, calea leptin-melanocortin |
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