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Neurologie. Neuropatologie. Sistem nervos (974) |
SM ISO690:2012 ROTARU, Lilia. Cerebrovascular disease associated with Parkinson’s disease in Moldovan cohort study. In: Moldovan Medical Journal, 2021, nr. 6(64), pp. 33-36. ISSN 2537-6373. DOI: https://doi.org/10.52418/moldovan-med-j.64-6.21.06 |
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Moldovan Medical Journal | |||||||
Numărul 6(64) / 2021 / ISSN 2537-6373 /ISSNe 2537-6381 | |||||||
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DOI:https://doi.org/10.52418/moldovan-med-j.64-6.21.06 | |||||||
CZU: [616.831-005+616.858](478) | |||||||
Pag. 33-36 | |||||||
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Background: Parkinson’s disease (PD) is frequently associated with brain vascular lesions (BVLs), which may influence the severity of the disease. Material and methods: BVLs on MRI were determined in 78.4% of 111 consecutive PD patients (mean age 64.87 ± 7.69 y.o.; disease duration 50.21 ± 38.61 mo.; 48 women (43.2%), 63 men (56.8%)). Results: White matter lesions were present in 73 patients (p.) (65.77%): 61p. (54.95%) – deep white matter, 46p. (41.44%) – periventricular white matter, and 41p. (36.94%) – both locations. Lacunas were determined in 19p. (17.12%), cerebral fissures deepening – 52p. (46.85) %), perivascular spaces dilation – 34p. (30.63%), ventricular system dilation – 29p. (26.13%). Patients with and without BVLs had similar ages, ages at PD onset and disease duration. They had insignificantly higher Beck (7.26 ± 5.62 vs 6.86 ± 4.34), PDQ39 (Parkinson’s Disease Questionnaire) (59.71 ± 20.38 vs 51.94 ± 27.69) and NMS (Non-Motor Symptoms) (75.06 ± 45.21 vs 71.67 ± 26.35) scores; and lower MoCA (Montreal Cognitive Assessment) scores (21.92 ± 4.25 vs 22.38 ± 4.57). QRISK3 scores (19.68 ± 16.16 vs 12.90 ± 6.58) and levodopa equivalent daily dose (639.98 ± 223.05 vs. 439.69 ± 404.87) were significantly higher in patients with BVLs. Conclusions: Brain vascular lesions were common in our PD patients, and were associated with higher QRISK3 scores and higher levodopa equivalent daily dose, suggesting more disease severity. |
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Cuvinte-cheie Parkinson’s disease, brain vascular lesions |
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