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Ultima descărcare din IBN: 2023-04-26 09:36 |
Căutarea după subiecte similare conform CZU |
616-006-053.1-091-076 (1) |
Patologie. Medicină clinică (6994) |
SM ISO690:2012 IAVORSCHI, Elvira, COTOROBAI, Mariana, NEDEALCOVA, Elena, ROTARU, Dorina, OLEINIC, Svetlana, IURCU, Tatiana, BRANIŞTE, Nina. Histiocitoza congenitală – dificultăți in diagnostic pe baza unui caz clinic. In: Buletin de Perinatologie, 2021, nr. 2(91), pp. 78-82. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 2(91) / 2021 / ISSN 1810-5289 | ||||||
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CZU: 616-006-053.1-091-076 | ||||||
Pag. 78-82 | ||||||
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Introduction. Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder most commonly characterized by single or multiple osteolytic bone lesions or skin rashes demonstrating infiltration with histiocytes with “bean-shaped” nuclei on biopsy with or without histiocytic infiltration of extraskeletal tissues (most notably the skin, lungs, lymph nodes, liver, spleen, bone marrow, brain, and pituitary gland). Objective. To present a clinical case of Langerhans cell histiocytosis (LCH) in a newborn girl and describe specific issues in diagnosing this condition. Method and materials. The present report presents a clinical case of Langerhans cell histiocytosis (LCH) in a newborn girl and describe specific issues in diagnosing this condition. Results. This article describes a clinical case of LCH in a newborn girl. At the age of 18 days, she presented with small macular hemorrhagic rash on the skin of the head, face and torso. The skin in the central portions of some small maculae had the appearance of ruptured pustules. The initial diagnosis was hemorrhagic disease. The child underwent clinical and paraclinical examination, consulted by a pediatric surgeon, hematologist, geneticist, dermatologist, allergist. In view, however, of both the failure of the skin lesions to improve with treatment, she was admitted to the intensive care unit of the IMSP IMC in critical condition, with a clinical diagnosis of sepsis with multiple organ dysfunction. In accordance with autopsy data, histopathological studies and morphopathological diagnosis, it was established that the cause of death was of Langerhans cell histiocytosis. Conclusion. LCH is a rather rare disorder with a wide spectrum of non-specific clinical manifestations, creating difficulties for diagnosis within the first days of hospitalization. Skin biopsy is required to confirm the diagnosis. Differential diagnosis is needed, to exclude other disorders manifested by a slowly evolving hemorrhagic rash. |
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Cuvinte-cheie Langerhans cell histiocytosis, newborns, hemorrhagic rash, Necropsy, гистиоцитоз из клеток Лангерганса, новорожденные, геморрагическая сыпь, аутопсия |
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