Background: Laparoscopic surgery for combined surgical pathology demands technique of simultaneous operations. The technique of simultaneous treatment of inguinal hernia (IH) and gallstone disease (GD) has been developed and tested. Material and methods: Prospected parameters were: heart rate (HR), variation range (ΔX), mode of the amplitude (AMo), and duration mode (Mo). The level of Index of Nervous Tension (INT) was evaluated by Baevsky method for estimating stress level and tension of sympathetic nervous system. Parameters were compared between control group (No1, n=76 one operation for IH) and simultaneous surgery group (No 2, n=58 IH+GD). In all cases laparoscopic transabdominal periperetoneal alohernioplasty was performed. Results: Heart rate was increasing after surgery, maximum after 2 h (by 26.3% and 23.3%, p>0.05); the ΔX in both groups decreased after 2 h (by 12.4% and 12.1%, p<0.05) and after 2 days (5.3% and 6.8%, p<0.05); Mo did not differ in both groups (p>0.05); the dynamics of the AMo increased with a maximum after 2 h (by 20.2% and 20.6%, p<0.05); the INT rate was increasing up to 2 hours postoperative (by 93.6% and 93.4% (p<0.05)). All indicators were back to normal rates within two days and did not differ in both groups. Conclusions: No difference in the level of tension in sympathetic nervous system and the degree of centralization of heart rate regulation was registered in both groups. Our developed technique has been shown safe and effective.