Studiul a avut scopul de a cerceta infl uenţa polizaharidelor sulfatate din Spirulina platensis (PSS) în doză de 1, 10 şi 125 mg/kg per os asupra modifi cărilor parametrilor sangvini la şobolani în condiţii fi ziologice. S-a stabilit că PSS în doza 1 mg/kg diminuează veridic numărul de eritrocite (RBC). PSS în dozele 1 şi 10 mg/kg infl uenţează slab intensitatea leucopoiezei şi limfopoiezei manifestat prin tendinţa de creştere a numărului de leucocite (WBC) şi a numărului absolut de limfocite (LYM). S-a observat efectul imunomodulator al PSS în doza de 125 mg/kg prin creşterea veridică al raportului procentual a limfocitelor şi tendinţa de majorare a numărului absolut de limfocite din sângele periferic.

Infl uence of Sulphatated Polysaccharides on the blood parameters of rats in physiological conditions The aim of the study was to investigate the infl uence of sulphatated polysaccharides from Spirulina platensis (PSS) in doses of 1, 10 and 125 mg/kg per os on blood parameters in rats in physiological conditions. It was established that PSS in dose of 1 mg/kg signifi cantly reduces the number of erythrocytes (RBC). PSS in doses of 1 and 10 mg/kg exerts weak effects on the intensity of leucopoiesis and lymphopoiesis manifested by an upward trend of the white blood cells (WBC) count and of the absolute number of lymphocytes (LYM). Immunomodulatory effect of PSS in dose of 125 mg/kg was observed which has been shown by the reliable increase of the LYM ratio and the tendency of increase of the absolute number of LYM in peripheral blood.